A8体育

邓诣群团队揭示细胞在胁迫条件下内稳态的调节机制

审核发布:A8体育-A8体育直播 来源单位及审核人: 生命科学A8体育 陈乐天 发布时间: 2019-08-19浏览次数: 10

2020NIAN8YUE15RI,A8TIYUSHENGMINGKEXUEA8TIYU、LINGNANXIANDAINONGYEKEXUEYUJISHUGUANGDONGSHENGSHIYANSHI、GUANGDONGSHENGNONGYESHENGWUDANBAIZHIGONGNENGYUDIAOKONGZHONGDIANSHIYANSHIDENGYIQUNJIAOSHOU、WENJIKAIJIAOSHOUTUANDUIZAINatureCHUBANJITUANQIXIAGUOJIZHUMINGXUESHUQIKAN Cell Death and Differentiation (SHENGWU1QUTop,IF2019: 10.717)ZAIXIANFABIAOTIWEI“Cell fate determined by the activation balance between PKR and SPHK1”DEYANJIULUNWEN(LUNWENLIANJIEDIZHI: http://www.nature.com/articles/s41418-020-00608-8),JIESHILEXIBAOZAIZHENJUNDUSU、XIJUNZHIDUOTANGDENGXIEPOTIAOJIANXIATONGGUOPKR/ SPHK1XINHAOTONGLUJIAOHUDIAOKONGXIBAODIAOWANGYUCUNHUO,CONGERWEICHIXIBAOWENTAIDEGUANJIANZUOYONGJILI。

XIBAODEJINGSHENGZHANGLVHEJINGSIWANGLVZHIJIANCUNZAIPINGHENG,ZHEIZHONGSHENGLINEIWENTAIHUISUIZHEGEZHONGXIEPOYINZICIJIERFASHENGGAIBIAN。PKRTONGGUOZILINSUANHUAJIHUOJIEDAODEXIBAOSIWANGHUODIAOWANG,SHIXIBAOZAIXIEPOTIAOJIANXIADEHEXINSHANGYOUFANYING。DANGWAIJIEXIEPO(RUOUTUDUSUHEXIJUNZHIDUOTANG)DADAOYIDINGYUZHI,SPHK1NENGGOUXIANGYINGDUOZHONGWAIYUANCIJIERBEILINSUANHUA,JIHUOS1PHECHENG,TONGGUOS1PDE“inside-out”DIAOKONGZHOUJIEDAOXIBAOCUNHUOXIAOYING。BENYANJIUZHENGMINGSPHK1SHIPKRDIWU,ZHEIZHONGPKRJIEDAODESPHK1LINSUANHUAJINYIBUJIHUOLES1P/S1PR1/MAPKs/IKKαSHENGCUNXINHAO。GENGZHONGYAODESHI,JIHUODESPHK1ZUOWEIFUDIAOKONGYINZIZHIJIEJIEHEPKRDEJIMEIJIEGOUYU,YIZHIPKRDEZILINSUANHUA,JIEKANGPKRJIEDAONEIZHIWANGYINGJIIRE1α/XBP1(s)/CHOPDEDIAOWANGXINHAO,CONGERZHONGXINDINGYIZHENJUNDUSUBAOLUDENGXIEPOTIAOJIANXIAXIBAODEMINGYUN。GAIYANJIUJIESHIDEFUFANKUITONGLUDUIYULIJIEXIBAOGOUJIANXINDENEIHUANJINGPINGHENGJUYOUZHONGYAOYIYI,BUJINYOUZHUYUJIASHENDUIPKRHESPHK1JIMEIGONGNENGHEXIBAOSHENGWUXUEGONGNENGDELIJIE,TONGSHIYEWANSHANLEXIBAOYINGJIXINGXIANGYINGZHENJUNDUSUDENGXIEPOYINSUDELILUNJICHU。

BENLUNWENDETONGXUNZUOZHEWEIDENGYIQUNJIAOSHOUYUWENJIKAIJIAOSHOU,DIYIZUOZHEWEI2017JIBOSHISHENGQIAOHAN。GAIYANJIUDEDAOLEGUOJIAZIRANKEXUEJIJIN-GUANGDONGLIANHEJIJINZHONGDIANXIANGMU、GUANGDONGSHENGZIRANKEXUEJIJINTUANDUIXIANGMUHEGUOJIAZHONGDIANYANFAJIHUAKETIDEZHICHI。(WEN/SHENGMINGKEXUEA8TIYU MUPEIQIANG  TU/SHENGMINGKEXUEA8TIYU QIAOHAN)


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A8体育 

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